| DATE | HOME | SCORE | AWAY | |||
|---|---|---|---|---|---|---|
| 02/04/2022 | GETAFE | 1 - 0 | MALLORCA | |||
| 02/04/2022 | LEVANTE | 2 - 0 | VILLARREAL | |||
| 02/04/2022 | CELTA DE VIGO | 1 - 2 | REAL MADRID | |||
| 02/04/2022 | ATLÉTICO MADRID | 4 - 1 | DEPORTIVO ALAVÉS | |||
| 03/04/2022 | ATHLETIC BILBAO | 2 - 1 | ELCHE | |||
| 03/04/2022 | REAL BETIS | 4 - 1 | OSASUNA | |||
| 03/04/2022 | GRANADA | 2 - 2 | RAYO VALLECANO | |||
| 03/04/2022 | VALENCIA | 0 - 0 | CÁDIZ | |||
| 03/04/2022 | BARCELONA | 1 - 0 | SEVILLA | |||
| 04/04/2022 | REAL SOCIEDAD | 1 - 0 | ESPANYOL |

